My research interests focus on lipid homeostasis, understanding how cells produce and store lipids depending on their needs. I primarily study lipid dynamics of the endoplasmic reticulum which is the hub of lipid synthesis and storage in the cell. In the lab, we use the power of yeast to develop genetic screens to identify genes playing key roles in these processes. Follow up investigations of these genes are performed both in yeast and human cells using molecular/cellular biology, biochemistry and fluorescent microscopy techniques.

Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV Jr. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. Journal of Cell Biology. (2020) Oct 5;219(10):e202006111. doi: 10.1172/JCI140494.

Becuwe M*, Gluchowski NL*, Walther TC, Farese RV Jr. Lipid droplets and liver diseases: from basic biology to clinical implications. Nature Review Gastroenterology and Hepatology. (2017) Jun;14(6):343-355. doi: 10.1038. *Co-First author.

Becuwe M and Leon S. – Integrated control of transporter endocytosis and recycling by the Rod1-Rsp5 ubiquitylation complex. Elife (2014). Nov 7;3. doi: 10.7554

Becuwe M, Herrador A, Haguenauer-tsapis R, Vincent O and Leon S. – Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family. (Invited review) Biochemical Research International (2012). 2012:242764.

Becuwe M, Vieira N, Lara D, Gomes-Rezende J, Soares-Cunha C, Casal M, Haguenauer-Tsapis R, Vincent O, Paiva S, Léon S. – A molecular switch on a yeast arrestin-like protein relays glucose signaling to transporter endocytosis. Journal of Cell Biology (2012) Jan 23;196(2):247-59.

Selected in the section “In focus” by Mitch Leslie (2012) Spare the Rod1, spoil transporter endocytosis. Journal of Cell Biology 196, 181

Joron M, Frezal L, Jones RT, Chamberlain NL, Lee SF, Haag CR, Whibley A, Becuwe M, Baxter SW, Ferguson L, Wilkinson PA, Salazar C, Davidson C, Clark R, Quail MA, Beasley H, Glithero R, Lloyd C, Sims S, Jones MC, Rogers J, Jiggins CD, ffrench-Constant RH. – Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mmicry. Nature (2011) Aug 14;477(7363):203-6.

• Harvard College Certificate of Distinction in Teaching Fall 2020, Spring 2021, Fall 2021, Spring 2022
• Doty-Losick Prize for Excellent Service - Department of Molecular and Cellular Biology – Harvard university (2021).
• Jane Coffin Childs postdoctoral fellowship (2015-2018)
• Fellowship from the Philippe Foundation (2016-2017)
• European Molecular Biology Organization Long term fellowship (2015)
• Fellowship from the French Research Ministry (2010-2013)