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First-Year Application Deadlines
Don't miss your chance to apply to Marist!
• Early Decision I and Early Action: Friday, Nov. 15
• Early Decision II and Regular Decision: Saturday, Feb. 15Academics
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• Early Decision II and Regular Decision: Saturday, Feb. 15Admission & Financial Aid
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Two students participating in a psychological study
Navneet Kaur
Visiting Lecturer of Chemistry
Bio
Dr. Kaur is an educator and researcher with a medicinal, process, natural, synthetic, and analytical chemistry background. She completed her Ph.D. in synthesizing and analyzing Silver selective macrocycles followed by a postdoc at the University of Central Florida in synthesizing anticancer drugs and their selective delivery to different cancer cells. As a medicinal chemist, she has designed, synthesized, and evaluated many new chemical entities as anticancer, anti-diabetic, anti-metastatic, anti-tuberculosis, and anti-inflammatory bowel disease drugs using structure-activity relationship (SAR). She joined as a senior scientist at Mannkind Corporation, Danbury, Conn. in 2008. She worked on developing an insulin inhaler (now in the market known as Afrezza). As a process chemist, she lowered the cost of the drug to 50% for the company. She has worked on all process development steps including route selection, scouting, optimization, and tech transfer from the lab to the pilot plant. Her career in teaching started in 2014 at Dutchess Community College. Since then, she has taught at SUNY, New Paltz, Bard College, Marist, and Vassar College.
Outside of Marist, she has been involved in community service in many ways like mentoring at Dutchess Chamber of Commerce for their youth leadership program, counseling high school students to prepare for college, teaching native language, preparing young adults for different cultural activities at Mid-Hudson Sikh Cultural Society, and working as a volunteer in the Clinical Research Group at Vassar Brothers Medical Hospital as Clinical Research Coordinator. She has also served as a judge at the Dutchess County Science Fair. She has been a member of the American Chemical Society (ACS), and the American Association of Clinical Chemistry.
Education
Postdoc, Medicinal Chemistry, University of Central Florida (UCF), Orlando, 2008
PhD, Organic Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India, 1997
MS (Hons.), Inorganic Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India, 1993
BS (Hons.), Chemistry, Guru Nanak Dev University, Amritsar, Punjab, India, 1991
Research Interests / Areas of Focus
Medicinal Chemistry, Selective Delivery of Anticancer Drugs using Polyamine Transporter, Macrocycles (Ionophores), Self-assembling molecules, Natural Products, Process Chemistry
Selected Publications
Synthesis and Biological Evaluation of Antimetastatic Agents Predicated upon Dihydromotuporamine C and Its Carbocyclic Derivatives. Aaron Muth, Veethika Pandey, Navneet Kaur, Melissa Wason, Cheryl Baker, Xianlin Han, Teresa R. Johnson, Deborah A. Altomare and Otto Phanstiel IV; J. Med. Chem. 57, 4023-4034. 2014.
Development of Polyamine Transport Ligands with Improved Metabolic Stability and Selectivity against Specific Human Cancers. Aaron Muth, Joseph Kamel, Navneet Kaur, Allyson C Shicora, Iraimoudi S. Ayene, Susan K. Gilmour and Otto Phanstiel IV; J. Med. Chem., 56(14), 5819-5828, 2013.
A Putrescine-anthracene conjugate: a paradigm for selective drug delivery. Andrew J. Palmer, Radiah A. Ghani, Navneet Kaur, Otto Phanstiel and Heather M. Wallace; Biochem. J., 424, 431-438, 2009.
Designing the Polyamine Pharmacophore: Influence of N-substituents on the transport behavior of polyamine conjugates. Navneet Kaur, Jean-Guy Delcros, Nathan Z. Weagraff and Otto Phanstiel IV; Journal of Medicinal Chemistry, 51, 2551-2560, 2008.
A Delineation of Diketopiperazine self-assembly processes: Understanding the molecular events involved in FDKP interactions. Navneet Kaur, B. Zhou, F. Breitbeil, K. Hardy, and O. Phanstiel, IV; Molecular Pharmaceutics, 5, 294-315, 2008.
A comparison of Chloroambucil- and Xylene-containing polyamines leads to improved ligands for accessing the polyamine transporter. Navneet Kaur, Jean-Guy Delcros and Otto Phanstiel IV; Journal of Medicinal Chemistry, 51, 1393-1401, 2008.
A Drosophila Model To Identify Polyamine-Drug Conjugates That Target the Polyamine Transporter in an Intact Epithelium. Chung Tsen, Mark Iltis, Navneet Kaur, Cynthia Bayer, Jean-Guy Delcros, Laurence von Kalm, Otto Phanstiel. J. Med. Chem., 51, pp 324-330, 2008.
Utilization of Fe3+-Acinetoferrin Analogues as an iron source by Mycobacterium tuberculosis. G. M. Rodriguez, R.Gardner, N. Kaur and O. Phanstiel IV; Biometals, 21, pp 93-103, 2008.
Structure-activity Investigations of Polyamine-anthracene Conjugates and their Uptake via the Polyamine Transporter. O. Phanstiel IV, N. Kaur and J-G Delcros; Amino Acids, 33, pp 305-313, 2007.
Modeling the Preferred Shapes of Polyamine Transporter Ligands and Dihydromotuporamine-C Mimics: The Shovel versus the Hoe. F. Breitbeil III, N. Kaur, J-G Delcros, B. Martin, K. Abboud and O. Phanstiel IV; Journal of Medicinal Chemistry, 49(8), 2407, 2006.
Selected Presentations
Synthesis and biological evaluation of Dihyromotuporamine derivatives in cells containing active polyamine transporters. Navneet Kaur presented at FAME, Orlando, USA, May, 2005.
Cell-Selective Drug Delivery Using Polyamine Active Transporters. Navneet Kaur, presented at Mayo Clinic, Jacksonville, FL, USA
Patents
Preparation of ethylfumarates and their use as intermediates in the synthesis of aminoalkyl-diketopiperazines. PCT Int. Appl., WO 2013162764 A1 20131031 (2013).
Polyamine transporter selective compounds as anticancer agents. U.S. Patent 8,497,398 (7/30/2013)
"Diagnostic tests for inflammatory bowel diseases" U.S. Patent 7,972,807 (7/5/2011)
Awards and Honors
- Reviewer of the Journal of Organic Chemistry
- Reviewer of the Journal of American Chemical Society
- Awarded Department of Science and Technology (DST) fellowship (1994-1996)
- Awarded Guru Nanak Dev University fellowship (1996-1997)
- Awarded fellowship from the Indian System of Medicine (ISM) (1997-2000)
- Awarded fellowship from Indian Council of Medical Research (ICMR) (2000-2001)
